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2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S

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studies on personalisation are now beginning to emerge, with a recent finding that genetic variations in the GLP-1 receptor, and also in arrestin B1, are important for the glycaemic effects of GLP-1 receptor agonists [105]