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The glucagon receptor component drives energy expenditure and hepatic fat mobilisation, a mechanism absent in earlier-generation incretin compounds

Most patients experience their most noticeable changes after the 12 to 16-week mark

Many of the cardiovascular and metabolic trials informing the discussion were not designed to evaluate ophthalmic outcomes. The authors called for prospective ophthalmology-specific studies incorporating imaging biomarkers, visual outcomes and disease-specific monitoring, noting that parsing the protective benefits or adverse effects of this rapidly growing medication class will be essential to refining disease management and improve patient outcomes. As GLP-1 therapies become increasingly common among patients with diabetes, obesity and vascular comorbiditiesprecisely the populations populating ophthalmic clinicsthe field may not have the luxury of waiting for cleaner data

[Published correction appears in Lancet

Recent advances have further highlighted the superior efficacy of dual GLP-1/GIP receptor agonists in managing OSA

The boxed warning also mentions the risk of pancreatitis and that the medication is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) and patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)