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Weeks 8 to 16 (3.0 mg): This period is clinically important for assessing response

Hozawa A, Ohkubo T, Kikuya M, Ugajin T, Yamaguchi J, Asayama K, Metoki H, Ohmori K, Hoshi H, Hashimoto J, Satoh H, Tsuji I, Imai Y

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Treatment usually begins at 0.25 mg once weekly and is titrated upward over months, up to a maximum of 2.4 mg for weight management, which lets the body adjust and keeps side effects manageable