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30 GLP1 receptor agonists physiology and hypoglycemia The response to oral glucose stimulates a higher and more sustained release of insulin than intravenous (IV) glucose, and that this is attributed to the effect of the 2 incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1)

Additionally, innovations in drug delivery methods, such as weekly dosing formulations, further enhance patient compliance, solidifying the dominance of this segment

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The primary interaction concern is with oral medications that depend on consistent absorption

However, rheumatologists uniformly emphasize that these medications should not replace disease-modifying antirheumatic drugs (DMARDs), biologics, or standard treatment protocols