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Metformin received FDA approval in 1994 for type 2 diabetes and with its beneficial effect on glycated hemoglobin (HbA1c), efficacy, and safety being wellestablished, 3 , 4 , 5 it became the recommended firstline choice for patients with type 2 diabetes in 2005

GLP-1 is a member of the incretin neuropeptide family, secreted by intestinal enteroendocrine L-cells of the distal ileum and large intestine [4, 5] and also in the nucleus of the solitary tract (NTS) in response to nutrient intake [6, 7]

Press the pen firmly into the injection spot and hold the trigger button

26% with placebo, Tables 2 and 3)

Subsequently, Lamers et al

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