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This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose At the four-week escalation schedule used in Phase 2 trials, participants reached the 12mg maximum dose at week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

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Best-corrected visual acuity was assessed using Sloan charts at distance after subjective refraction

In Covid-19, ED (a hallmark of the disease) and activation of adhesion molecules trigger the progression of immunothrombosis and the development of critical complications (Bonaventura et al