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By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

J Cardiovasc Pharmacol 83(3):243250

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From a clinical perspective, GLP-1s are generally safer with fewer abuse concerns, while phentermine has stimulant effects and contraindications in cardiovascular disease

The Power of Lifestyle: The main strength of this approach is that it is sustainable and completely non-invasive