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Conclusively, therapy with exenatide and rosiglitazone, in addition to metformin, offset the weight gain observed with rosiglitazone and elicited an additive effect on glycemic control with significant improvements in -cell function and insulin sensitivity

Regarding safety, the most common adverse events associated with Retatrutide were gastrointestinal-related

We further assessed potential effect modification according to clinical stage and Gleason score at prostate cancer diagnosis, i.e

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Maintaining weight loss after tirzepatide through diet, exercise, and potentially a lower GLP-1 maintenance dose helps preserve these protective effects