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In the SURMOUNT-1 trial, participants without diabetes lost an average of 15-20% of their body weight over 72 weeks at the 10 mg and 15 mg doses, though results may vary in different populations

However, consuming large amounts of fibre without sufficient hydration can worsen constipation

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Previously, multinational pharmaceutical companies like Eli Lilly, Novartis, and Johnson & Johnson (J&J) also attempted to develop obesity treatments targeting GDF15