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ANS (2-4,7) : This occurs primarily through following two mechanisms: (A) GLP-1RAs are highly effective for weight reduction

While these medications offer new hope for adolescents struggling with obesity, their use must be guided by evidence-based protocols, careful patient selection, and ongoing research to address remaining knowledge gaps

Trade-offs include less flexibility in dose adjustment and prolonged exposure if adverse effects develop

doi: 10.3389/fendo.2021.721198 [DOI] [PMC free article] [PubMed] [Google Scholar] 120

Some patients achieve better tolerability by switching between injectable and oral formulations or between different GLP-1 compounds

What It May Support Activates both GIP and GLP-1 receptors, a combined mechanism associated with stronger average results in clinical trials