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Clinical development is now in the Phase 3 TRIUMPH registrational program a multi-trial registrational basket spanning obesity, obstructive sleep apnoea, knee osteoarthritis, type-2 diabetes, MASLD/NASH, and chronic kidney disease across more than 5,800 participants

It underscores the need for more frequent monitoring when starting tirzepatide, a point we will return to in the monitoring section

These adverse conditions include gastroparesis (a condition that affects the normal movement of the stomach muscles), ileus (a painful obstruction of part of the intestine), gallbladder disease, and pancreatitis

To learn more about this topic, refer to the resources below, which support observations in this article

And in 2025, there were 46