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doi: 10.1111/dme.13629 24 McGuireDKZinmanBInzucchiSEWannerCFitchettDAnkerSDet al

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By combining all three actions into one therapy, Retatrutide demonstrates greater weight loss potential and metabolic improvements compared to single-pathway treatments such as semaglutide alone

Fisman EZ, Tenenbaum A

GLP-1 was discovered in the 1980s, and GLP-1RAs have been around for about 20 years (the first one approved for humans was a synthetic version of a molecule isolated from the venom of Gila monsters), but recent development of new versions of this type of drug are revolutionising treatment of diabetes and obesity