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the improvement effects of the NPs and MNs treatment groups were not obvious, while the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups could effectively alleviate cartilage destruction and osteophyte formation, especially the MNs/GLP-1RAs@NPs-WYRGRL group (Fig
This is the first study of its type looking at longer-term maintenance with an oral GLP-1 after taking an injectable, said Dr
It has been documented that there are some complementary actions between metformin and GLP-1-based drugs such as GLP-1 analogue and dipeptidyl peptidase 4 inhibitor 20
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After the 12-wk study period, GLP-1 users showed significant ( P s 0.23
