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260 GLP-1 downregulated Na+/H+ exchanger isoform 3 in the renal proximal tubule of rats, suggesting that GLP-1 could be used to treat hypertension and sodium retention disorders

The majority of intestinal K cells are located in the proximal duodenum

Salome Alfaro: validation (equal), writing review and editing (equal)

The prevalence of bullous pemphigoid was 0.0859% in total, with a trend toward a higher risk associated with vildagliptin use compared to the other DPP-4 inhibitors ( In total, however, the DPP-4 inhibitor class has demonstrated a good safety and tolerability spectrum that justifies the wide use of the class

Salacia Reticulata Improves Serum Lipid Profiles and Glycemic Control in Patients With Prediabetes and Mild to Moderate Hyperlipidemia: A Double-Blind, Placebo-Controlled, Randomized Trial

Clinical concern regarding skeletal muscle changes during GLP-1RA therapy remains debated [40], and preclinical studies have reported context-dependent protection against muscle wasting in selected settings [42, 43]