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GLP-1 analogues possess anti-catabolic activity, as demonstrated by reduced MMP-3 and MMP-13 , ADAMTS4 , ADAMTS5 mRNA expression in TNF-stimulated human chondrocytes that was correlated with increased aggrecan and type II collagen protein levels [42,43]

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Although most patient charts may state a patient has a diagnosis of anxiety and depression, their specific codes are not the same