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So-called non-responders are people who lose less than 5% of their body weight after roughly six months of treatment on the highest tolerated dose

Israelsen, et al

[2] Regular monitoring is essential, including blood tests to assess disease activity (CRP, ESR), drug safety (liver and kidney function, blood counts), and periodic imaging to detect joint damage

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It's not necessarily a listed 'top' side effect, but in real-world usage dry mouth is likely affecting hundreds of thousands of people in the UK ." says Oralieve

Visual acuity as an outcome measure in clinical trials of retinal diseases