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Originally developed for diabetes, these medications including Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro) have become some of the most effective tools for medical weight loss available today

At the proteolytic level, GLP-1 RAs may reduce muscle protease activity and modulate inflammatory pathways, thereby attenuating protein breakdown and contributing to muscle mass preservation [39, 84]

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Regular physical activity, even at modest intensity, can paradoxically improve energy levels by enhancing cardiovascular fitness, preserving muscle mass, and improving sleep quality

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