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Clinical trial data from FDA-approved labeling typically report gastrointestinal adverse effects broadly, with nausea occurring in 1544% of patients depending on the specific agent and dose, while vomiting affects 524% of users

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Real-world effectiveness depends on multiple factors: adherence to the weekly injection schedule, tolerance of side effects, individual metabolic responses, and commitment to supporting lifestyle changes

, (LSM [95% ] : -1,68 [-1,91, -1,46] / -1,22 [-1,45, -1,00] /

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But this slowed gastric emptying also leads to increased fermentation of food by gut bacteria, which leads to the formation of hydrogen sulfide gas