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While Wegovy and Zepbound added non-weight-loss indications, this second payer, instead, moved to outright rejecting claims between 70% and 80% of the time

GLP-1 drugs like Wegovy and Zepbound are highly effective but costly

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However, the current literature reveals a lack of in vivo studies on specific GLP-1R agonists such as semaglutide, necessitating further research to elucidate its precise mechanisms and effects, particularly in cancer

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Given the heterogeneity of the included evidencespanning case reports, pharmacovigilance analyses, and observational cohortsthis review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis