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, Leng, G

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Semaglutide is contraindicated in patients with: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Common Adverse Effects According to clinical trial data, gastrointestinal effects are most frequently reported: nausea, vomiting, diarrhea, constipation, and abdominal discomfort

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When SCFAs, a metabolite of GM, was supplemented to antibiotic-treated mice, IGF-1 and bone mass were restored to the levels of normal mice, suggesting that the restoration of the GM in germ-free mice is mediated by the production of SCFAs, which induces circulating levels of IGF-1 and thus has an effect on bone metabolism (Yan et al., 2016)

Poster presented at the American Diabetes Association (ADA)