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Description
These effects particularly are relevant in preventing adverse remodeling and heart failure progression [43]
FDA-labeled warnings include: Risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Pancreatitis (report severe abdominal pain, with or without vomiting) Gallbladder disease (including gallstones and cholecystitis) Acute kidney injury secondary to dehydration from gastrointestinal symptoms Hypoglycemia when used with insulin or insulin secretagogues (dose adjustments may be needed) Diabetic retinopathy complications in patients with type 2 diabetes and pre-existing retinopathy Suicidal behavior and ideation (monitor for depression or suicidal thoughts) Intestinal obstruction/ileus (particularly with severe constipation) These medications are contraindicated during pregnancy and should be discontinued at least two months before a planned pregnancy
tissue Int
Available from: 2025 The Author(s)
Immunocytochemical studies suggest two pathways for enteroendocrine cell differentiation in the colon
Besides the cost of medications, there are indirect costs like travelling, lost time at work, and frequent clinic visits which also limit access
