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Description
Structural basis for activation of the growth hormone-releasing hormone receptor
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The dosage schedule when switching after high-dose tirzepatide accounts for this partial adaptation and can help minimize the transition diarrhea

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Abbreviations GLP-1, glucagon-like peptide-1

Phase 2 trial data (NEJM, 2023) reported a mean body weight reduction of approximately 24% over 48 weeks at the highest dose, though larger Phase 3 trials are needed to confirm these findings