semaglutide hold for surgery 🩺✨ Why You Need to Stop GLP-1s Before (Ozempic, Wegovy, Mounjaro & more!), If you’re on a GLP-1 medication like Ozempic, Wegovy, Zepbound, or Mounjaro, it’s so important to stop it before Semaglutide and Anesthesia. Semaglutide causes

What to expect: Some reduce dose

Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users

In addition to diet and lifestyle changes, tesofensine can help optimize dopamine response in obese patients

It functions as a negative allosteric regulator, reducing the affinity of oligomeric A and interfering with A-induced synaptic toxicity [57]

doi: 10.1016/j.ejphar.2015.09.024

The GLORY-1 trial used 4 mg and 6 mg maintenance doses