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Measurement of plasma insulin concentration Insulin concentration in plasma samples collected from DIO mice at 8, 16, and 24 weeks after the initial treatment of the pharmacodynamic study was determined using a mouse insulin ELISA kit (Mercodia) according to the manufacturers protocols

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Based on clinician-documented diagnoses and diagnostic coding within the electronic medical record, one discontinuation was attributed to pancreatitis and three to gallstones (cholelithiasis)

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