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Monitor for side effects, particularly nausea, vomiting, diarrhea, and constipation

Treatment with the GLP-1MK-801 conjugate potently reverses obesity, diabetes and dyslipidaemia in a wide range of rodent models of obesity and metabolic disease

Regarding glucose-metabolism, two studies found that GLP-1(9-36), GLP-1 (7-36) and Liraglutide significantly inhibited insulin-stimulated glucose uptake [12, 13], with Liraglutide showing a dose dependent inhibition, with a maximum at a concentration of 1000 nM [12, 13]

35 A total of 56 patients was assessed using the ChildPugh criteria and grouped into either normal, mild, moderate, or severe hepatic impairment

However, the results showed that in addition to the cardiovascular safety of GLP-1 receptor agonists, some drugs in the class can have influence on major adverse cardiovascular event (MACE) reduction compared to placebo (37)