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Peters VA Medical Center

Taken together, these observations suggest that a reduction in the deceleration of gastric emptying may occur even within 4 hours of administration of exogenous GLP-1RAs (20)

In contrast, gastrointestinal side effects were reported in 10 of the 11 studies and were consistently more common in the intervention groups

doi: 10.1186/s12889-022-12833-6

Earlier in March, FDA released a similar announcement ending the compounding of tirzepatide (a GLP-1 drug used in Mounjaro & Zepbound)

Notably, GLP-1RA characterized by signaling bias favoring cAMP production over beta-arrestin recruitment has been regarded as more effective in controlling glucose and body weight in experimental mice compared to unbiased agonists [43, 44]