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It invented a new GLP-1 mimic, semaglutide, that could be injected once a week

doi: 10.1139/y69-020 [DOI] [PubMed] [Google Scholar] 9

Conversely, sacubitril/valsartan has been shown to increase PRA, ANG I and ANG II levels in a canine model of RAAS activation

Lancet 393 , 17451759 (2019)

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None of the AEs led to premature treatment discontinuation