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Tirzepatide 15 mg led to higher discontinuation rate of study medication due to adverse events regardless of comparator, while all tirzepatide doses were safe in terms of serious adverse events and mortality

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(For a detailed history, I recommend Megan Molteni and Elaine Chens piece for STAT.) The benefits of these drugs are undeniable, but when it comes to evaluating their risks, we run into challenges that researchers are familiar with but that the public at large may not be aware of

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