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developed a dual GLP1R/LepR agonist and evaluated its physiological efficacy in several mouse models, though the synergistic effect of the GLP-1 and leptin remains unclear due to technical issues (17)

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Dulaglutide administration at doses of 50, 100, and 150 g/kg significantly reduced colon weight, the weight-to-length ratio, both macroscopic and microscopic colonic changes in inflammation, and decreased serum CRP and LDH levels

This occurs because semaglutide's appetite-suppressing effects reverse, gastric emptying returns to normal speed, and the metabolic adaptations that occur with weight loss (including reduced energy expenditure) persist