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Higher doses increase gastrointestinal side effects without proportional benefits

I think back to a year ago, and I was mentally and emotionally drained

Increases in Heart Rate In placebo-controlled trials, OZEMPIC 0.5 mg and 1 mg resulted in a mean increase in heart rate of 2 to 3 beats per minute

Genetics, Response Patterns, and Personalized Therapy Selection Your genes influence how strongly your GLP-1 and GIP receptors respond to medication, which helps explain why two people on identical doses experience vastly different hunger suppression and weight loss

Absent any big surprises, though, the bigger question is what to do about it