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Additionally, incretin-based therapies as a class carry a rare signal for pancreatitis , and rapid weight loss is associated with an increased risk of gallbladder disease (including gallstones)

However, certain conditions (like a history of MTC or active pancreatitis) would be contraindications

Your gut lining adapts to the slower emptying rate, and your brain recalibrates its hunger signals

However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study) evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatide was observed in high-risk diabetic subjects

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