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While GLP-1 medications themselves do not typically cause significant hypotension directly, several mechanisms may contribute to blood pressure reduction

however, severe or persistent gastrointestinal symptoms may warrant dose slowing or medication adjustment

Hair loss has been reported by approximately 1 in 20 Wegovy users

1,6,7 Insulin requires multiple daily injections, can lead to weight gain, and carries the risk of hypoglycemia, which causes significant morbidity

Optional: If youre struggling to descend low enough, place 2.5 or 5-pound weight plates under your heels to enable greater depth

DPP-4 is highly expressed within enterocytes, the major absorptive epithelial cell type, and genetic elimination of Dpp4 expression within cells targeted by Vil1 -Cre reduces intestinal DPP-4 activity by up to approximately 90% (20)