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While the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron is in-line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury which resolved after discontinuation of danuglipron

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Peak GLP-1 increases were significantly higher (~32%) after RYGB at both follow-ups (p<0.05)

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Semaglutide subcutaneous and dulaglutide reduced stroke cases

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