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For example, Nagashima and colleagues showed that administration of active GLP-1(736) amide via osmotic minipumps for 4 weeks decreased atherosclerotic lesions and macrophage numbers in the aortic wall in Apoe / mice on high-fat diet (HFD), compared with vehicle controls (1)

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So what we say is this though

67 GaultVAO'HarteFPMHarriottPMooneyMHGreenBDFlattPRet al

Long-term data on microdosing maintenance protocols remains limited, but the clinical logic is sound and an increasing number of practitioners are adopting this approach

In many cases, the metabolic benefits of these medications may outweigh theoretical concerns, particularly for patients with significant obesity or poorly controlled diabetes, which themselves carry health risks