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Journal of Investigative Medicine High Impact Case Reports

Caloric restriction increases serum testosterone concentrations in obese male subjects by two distinct mechanisms

Significant reductions are often seen after three to six months of treatment

Optional Performance Add-Ons (Only If Tolerated) Once protein, hydration, electrolytes, and a basic plan are stable, you can consider performance add-ons

Efficacy estimand This estimand is used to assess the average treatment effect of bimagrumab, semaglutide or bimagrumab plus semaglutide for all randomized participants at weeks 48 and 72 had they received at least one dose of study treatment, adhered to protocol-defined treatment and did not discontinue treatment prematurely

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