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Abstract Introduction Congenital and acquired damage to hypothalamic nuclei or neuronal circuits controlling satiety and energy expenditure results in hypothalamic obesity (HO)

however, several drugs (including Novo Nordisks Wegovy and Eli Lillys Zepbound/Mounjaro) have recently been approved for chronic weight management

The next question to consider is the one of whether PPG neurons are a homogenous cell population, specifically activated by various forms of stress (including abnormally large meals), which then orchestrates the various responses of the body, including hypophagia and tachycardia
