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New England Journal of Medicine (2021) PMID: 33567185 STEP 1 randomized trial showing 14.9% mean weight loss at 68 weeks on semaglutide 2.4mg weekly

In hypertension models, GLP-1 RAs exert beneficial effects through multiple mechanisms including vascular vasodilation, diuresis, decreased sympathetic activity in the central nervous system, and reduced blood pressure variability (BPV) [15]

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Additionally, neuroprotective effects offered by Retatrutide make it a potent treatment option for neurodegenerative disorders such as Alzheimers Disease & Multiple Sclerosis

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