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New York: Medscape

While researchers found that GLP-1 drugs collectively showed positive impact on managing type 2 diabetes by effectively lowering haemoglobin A1c and fasting plasma glucose levels, higher doses of these drugs were shown to significantly increase adverse gastrointestinal reactions

Making the right choice between these medications, when retatrutide eventually becomes available, will depend on individual circumstances, risk tolerance, and clinical needs

and M.W.S

Second, long-term data on the cardioprotective efficacy of high-dose oral semaglutide remain lacking

It found a substantially increased risk of deep vein thrombosis (DVT) for patients taking semaglutide drugs to treat type 2 diabetes