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GLP-1based therapies share several common adverse effects and carry some rare but important risks

The first and original use is for type 2 diabetes management , where GLP-1 agonists help lower hemoglobin A1c levels by 1.02.0% on average, with the additional benefit of promoting modest weight loss rather than weight gain seen with some other diabetes medications

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Recent comprehensive reviews of the many GLP-1 agonists that have come to the market in the last 20 years have been published elsewhere [8,37]

But the best outcomes come from pairing the medication with: A plan you can actually follow A strategy for side effects A maintenance plan for the long haul And a serious commitment to protecting muscle with protein and strength training If youre thinking about starting, the most important question is not Which drug is best? Its: What is the safest plan that I can sustain, and how are we supporting my future self? References (APA) Aronne, L

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation