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GLP-1 is rapidly degraded by DPP-4 under normal circumstances

Beyond managing diabetes and obesity, emerging research is exploring GLP-1s for everything from treating addiction and lowering cardiovascular risk, to reducing knee pain

If youre on a medication that has weight gain as a side effect, that will likely affect your response to a GLP-1

These medications work by enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite

Furthermore, SP can directly inhibit insulin-dependent glucose metabolism in rat adipocytes (81)

Weight loss effects comparable to prescription GLP-1 medications are not substantiated by supplement research