glp-1 kidney cancer and the kidney: from physiology to pharmacology and outcomes in diabetes GLP-1 receptor agonists and cancer

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Interestingly, defects in mitochondrial energy metabolism are also present in the brains of patients with AD, leading to neuronal apoptosis and A deposition, which increases ROS production by interfering with mitochondrial calcium homeostasis and ETC function

GLP-1 acts on the brain to induce feelings of satiety, thus reducing appetite and leading to weight loss

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While the intraluminal delivery of bile acids stimulated GIP secretion in rats [62], chenodeoxycholic acid (CDCA), one of the primary bile acids and an agonist of G-protein-coupled bile acid receptor-1 (GPBAR-1), attenuated rather than enhanced postprandial GIP secretion in human subjects [63]

N Engl J Med 2020;382:211728.ArticlePubMed 39