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Recent studies using scintigraphy suggest that long-acting GLP-1 RAs may have fewer gastric effects than short-acting formulations due to the phenomenon of tachyphylaxis [20]

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Drucker said that it is critical to keep investigating not just their mechanisms of action and potential benefits, but also their safety

Notably, most available studies lack direct assessments of muscle strength, physical performance, or gait speed

This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

[DOI] [PMC free article] [PubMed] [Google Scholar] [82].Rinaman L