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Additionally, there is a boxed warning regarding thyroid C-cell tumors observed in rodent studies

Sitagliptin Add-on Therapy in Patients with Type 2 Diabetes Inadequately Controlled on Metformin Alone In a 24-week placebo-controlled trial of sitagliptin 100 mg administered once daily added to a twice daily metformin regimen, there were no adverse reactions reported regardless of investigator assessment of causality in 5% of patients and more commonly than in patients given placebo

Medical communities have started talking about the connection between GLP-1 medications and changes in mood, including anxiety symptoms

But Pfizer seems to have concluded that the toxicity question mark would damage its ability to compete in a relatively crowded space

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Keep reading to learn more, explore the FAQs below and visit the Quarterly Drug Pipeline for deeper insights into these anticipated therapies in development