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This epidemic significantly increases the risk of various comorbidities, including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), certain types of cancer, and kidney disease [3-6]
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These changes confirm the medication is working at a metabolic level, not just suppressing appetite

1998;275(5 Pt 1):G984G992

Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy