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Dipeptidyl peptidase-4 (DPP-4) cleaves these hormones, acting in an inhibitory manner to regulate the physiological action of endogenous incretin

Diabetes Care 47(11):18731888 Giorda CB, Rossi A, Baccetti F et al (2023) Achieving good metabolic control without weight gain with the systematic use of GLP-1-RAs and SGLT-2 inhibitors in type 2 diabetes: a machine-learning projection using data from clinical practice

171 The development of small molecule GLP-1RAs aims to overcome some of the limitations of traditional protein or peptide-based GLP-1RAs, such as the need for injection

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"While GLP-1 medications affect gastrointestinal tract motility, their quantified impact may not be as significant as previously assumed, said corresponding author, Dr Walter Chan, director of the Center of Gastrointestinal Motility and a physician in the Brigham's Division of Gastroenterology, Hepatology and Endoscopy