glp 1 agonists adverse effects GLP-1RA Essentials in Gastroenterology: Side Effect Management, Precautions for Endoscopy and Applications for Gastrointestinal Disease Treatment glp 1 indigestion Full article:

doi: 10.1210/endo.136.8.7628397 52 VilsbllTAgersHLauritsenTDeaconCFAaboeKMadsbadSet al

14,15 Another meta-analysis of 93 clinical trials showed that GLP-1 RAs increased the risk of early-stage DR compared with placebo, with this effect being driven by albiglutide in particular

Support Your Gut Health If youre thinking, Wait, thats it

Plans that delay formulary addition should expect to start seeing formulary exception request submissions

In practice, clinicians compare the mechanisms of the common GLP-1 drugs and choose one that matches your medical history, preferences, and response over time

Findings: WEIGHT LOSS IN ADOLESCENTS The STEP TEENS study detailed below evaluated the effects of Wegovy on weight loss in obese adolescents aged 12 - 17 years RCT STEP TEENS Study - Wegovy vs Placebo for Weight Loss in Obese Adolescents, NEJM (2022) [PubMed abstract] The STEP TEENS study enrolled 201 obese adolescents aged 12 - 17 years Main inclusion criteria Age 12 to 10% Baseline characteristics Average age 15.4 years Female sex - 62% Average weight - 238 lbs (108 kg) Average BMI - 37 Randomized treatment groups Group 1 (134 patients): Wegovy 2.4 mg once weekly Group 2 (67 patients): Placebo Before treatment, all patients underwent a 12-week run-in phase where they received lifestyle interventions Wegovy was started at 0.25 mg once weekly and titrated to 2.4 mg over 16 weeks Percentage change in BMI from baseline to week 68 Primary outcome: Results Among adolescents with obesity, once-weekly treatment with a 2.4-mg dose of semaglutide plus lifestyle intervention resulted in a greater reduction in BMI than lifestyle intervention alone Findings: Summary Wegovy caused impressive weight loss in the STEP TEENS study, and its effects were greater than other drugs approved for adolescent obesity (see Qsymia and Saxenda)