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This growing body of evidence suggests that the risks of these medications may have been knownor should have been knownlong before adequate warnings were provided

doi: 10.1016/j.molmet.2018.12.001 [DOI] [PMC free article] [PubMed] [Google Scholar] 71

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Wherein, the phosphorylation of the C-terminus by ERK1/2 recruits -arrestins to sterically hinder interactions with GPCR kinases, initiating endocytosis likely via the assembly of clathrin-coated pits [24, 33]

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In essence, this review presents a unique approach that focuses on tackling biological aging rather than just age-related illnesses