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One crucial observation made in the early clinical trials with GLP-1RA was that treated patients consistently lost weight relative to controls receiving placebo
2006 Nov [cited 2019 Jul 19];41(11):107687
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This complication was much more common with phenformin therapy, the initial biguanide, and the risk with metformin is estimated to be 20 times less (53)
9 Assessment of aversion in rodents
The treatment of type 2 diabetes requires positive modulation of GLP-1R to inhibit glucagon secretion and stimulate insulin secretion in a glucose-dependent manner
