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In rodents, this behavior can be studied in the operant self-administration model (Sanchis-Segura and Spanagel, 2006)

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This means each escalation step allows the compound to reach equilibrium before the researcher assesses tolerance and decides whether to proceed to the next dose level

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A repeat colonoscopy was performed, and gross examination showed diffuse mild inflammation found from 20-40 cm proximal to the anus secondary to colitis (Figure 2)

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The kits were also bulky and required soldiers to carry six autoinjectors in total

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