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Most have been classified as Category 2 bulk drug substancesmeaning the FDA has identified safety concerns and prohibited licensed compounding pharmacies from using them in human medications

Lpez-Ferreras et al., 2019, 2018

Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, et al

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For example, football players may fall into the category of grade 1 obesity if just using BMI to classify their weight status
Pharmacologically, signaling studies demonstrate that tirzepatide mimics the actions of native GIP at the GIP receptor but shows bias at the GLP-1 receptor to favor cAMP generation over -arrestin recruitment, coincident with a weaker ability to drive GLP-1 receptor internalization compared with GLP-1
